Eman A Bseiso
October 6 University, Egypt
Title: Intranasal lipid nanocarriers systems for treatment of oxidative diseases
Biography
Biography: Eman A Bseiso
Abstract
The objective of the current study was to assess the feasibility of nose to brain delivery of melatonin (MEL) using a lipidic nanocarrier (LNCs) for treatment of oxidative diseases. This carrier was chosen owing to its small size and biocompatible nature and is prepared using solvent-free phase inversion temperature technique. Design of experiment was used to establish D-optimal mixture design to study the impact of individual and combined effects of three independent variables; X1 (Oil), X2 (Surfactant), and X3 (Drug), on three LNCs responses; Y1 (particle size), Y2 (Polydispersity index) and Y3 (Zeta potential). MEL-LNCs were successfully prepared and characterized in terms of size, PDI and zeta potential. In-vitro drug release profiles and viscosity were assessed for the optimized LNCs. Results showed that all LNCs had a particle size ranging from 20-200 nm which was appropriate for intranasal permeability and brain targeting. They mostly exhibited narrow size distribution and a negative charge. They also exhibited a sustained release behavior. LNCs were shown to be a promising delivery system for possible nose to brain delivery of MEL.