Structural Biology

3D Structure Determination

3D structure determination involves uncovering the three-dimensional shape of biomolecules like proteins and nucleic acids using techniques such as X-ray crystallography, NMR spectroscopy, and cryo-electron microscopy (cryo-EM). These structures reveal how molecules function, interact, and change during biological processes. Understanding a molecule’s 3D shape is essential for identifying active sites, designing drugs, and engineering proteins for therapeutic or industrial use. Accurate structural data also provides insights into disease mechanisms and enables structure-based drug discovery, making it a cornerstone of modern biomedical research.